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KMID : 0371319740160060001
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Journal of the Korean Surgical Society
1974 Volume.16 No. 6 p.1 ~ p.7
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Antibacterial Effect of Pig Skin lieterograft as a Biologic Dressing
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Abstract
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Homografting and heterografting have become well known techniques to obtain temporary closure of burn wounds or open infected wound. The prime benefit of heterografting is the limitation of the infection. With this dressing the wound is closed to invasive infection and contamination is decreased. Homograft and heterograft skin used as temporary biologic dressing have confirmed both experimentally and clinically such a sterilizing activity on underlying contaminated
granulating wound bed. The present study was undertaken to evaluate the antibacterial effect of the partial thickness skin wound dressings.
The effect on bacterial counts of` two types of porcine skin, fresh or lyophilized, used as a dressing over infected wounds has been evaluated in 30 rat experiments. The result was summarized as followings;
(1) Surface bacterial count of the infected wound began to decrease significantly by the 2nd day with the fresh porcine skin coverage compared with lyophilized porcine skin which began to decrease by 4th day and decreased significantly by the 8th day with the lyophilized porcine skin dressing as well as fresh porcine skin dressing. The surface bacteria persisted even though underlying granulation became sterile.
(2) Bacterial counts within the wound tissue decreased by the 8th day with biologic dressing
coverage. Bacterial counts fell by 95% and the wound was sterile in 40~60% of the experiments. (3) Skin viability is seemed to be not essential for the antibacterial effect of a biologic dressing. (4) It is our observation that intimate adherence of the biologic dressing to the underlying
infected wound invariably preceded decrease in bacterial count or wound sterilization.
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